- Information
- AI Chat
DNA Replication
Foundations of Biomedical Science 1
King's College London
Recommended for you
Preview text
Semi conservative process: Produce 2 copies that each contain one original strand and one new strand
Helicase breaks H-Bonds between the DNA strands and unwinds them, creating a replication fork
DNA Gyrase reduces torsional strain from unwinding by relaxing positive supercoiling
Single Stranded Binding Proteins bind to the single strand DNA and prevent them from re-annealing as well as being digested from nucleases, and will be dislodged when DNA polymerase III synthesises a complementary strand
DNA Primase acts as an initiation point for DNA polymerase III to act on by adding RNA primers, which can only extend but not start a nucleotide chain
DNA Polymerase III joins free nucleotides together in a 5' - 3' direction. There is a leading strand and a lagging strand. On the leading strand, replication moves toward the replication fork and can synthesise continuously. On the lagging strand, DNA polymerase III moves away from the replication fork and synthesises in pieces.
DNA Polymerase I removes the RNA primers placed and replaces them with DNA nucleotides
DNA Ligase joins the Okazaki fragments to form a continuous strand on the lagging strand
DNA Replication
Thursday, 27 September 2018 22:
DNA Replication
Module: Foundations of Biomedical Science 1
University: King's College London
