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Genetics of Inflammation
Genetics of Inflammation
Module
Foundations of Biomedical Science 1
221 Documents
Students shared 221 documents in this course
University
King's College London
Academic year: 2018/2019
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Understand that there is a spectrum of autoimmune/inflammatory
disorders
K (details not needed to be known)
Overview of disease progress: IBD, psoriasis, SLE with
differences/commonality between them
Psoriasis Itchiness, cracked skin, pain, pitted nails, arthritis Caused by: - Infections (e. Streptococcal, viral) - Skin trauma (Kroebner phenomenon) - Psychological stress - Drugs (e. Li, ß blockers) - Sunburn - Metabolic factors (e. Ca deficiency) - Hormonal factors (e. Pregnancy)
Genetics of Inflammation
Tuesday, 9 April 2019 13:
Relevance of GWAS to therapy and drug discovery in AID
Notes
Four Hypotheses for IBD - Persistent infection
- Defective mucosal integrity - Gut cannot protect itself from the beginning Dysbiosis - Decrease in protective bacteria and increase in aggressive commensals
•
- Dysregulated immune response - Body starts to attack the gut
Was this document helpful?
Genetics of Inflammation
Module: Foundations of Biomedical Science 1
221 Documents
Students shared 221 documents in this course
University: King's College London
Was this document helpful?
Understand that there is a spectrum of autoimmune/inflammatory
disorders
K (details not needed to be known)
Overview of disease progress: IBD, psoriasis, SLE with
differences/commonality between them
Psoriasis
Itchiness, cracked skin, pain, pitted nails, arthritis
Caused by:
Infections (e.g. Streptococcal, viral)
•
Skin trauma (Kroebner phenomenon)
•
Psychological stress
•
Drugs (e.g. Li, ß blockers)
•
Sunburn
•
Metabolic factors (e.g. Ca deficiency)
•
Hormonal factors (e.g. Pregnancy)
•
Genetics of Inflammation
Tuesday, 9 April 2019
13:11
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