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Synthesis of Phenytoin
Organic Chemistry II (CHEM 3223)
Texas Woman's University
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CHEM 3221 02
March 27, 2021
Introduction: Phenytoin is being synthesized from the formation of Benzoin and Benzil.
Schemes:
CHEM 3221 02
March 27, 2021
Safety: - Concentration acetic acid is corrosive to skin and mucous membranes. Do not get on skin or inhale the vapors. - Sodium and potassium hydroxide and their solutions are severe irritants to skin and other tissue. - 5,5-diphenylimidazolidine-2,4-dione (phenytoin) is toxic in pure form. Do not get on skin. Always handle with gloves. - All organic compounds used and synthesized in the experiment are irritants to skin and eyes. Experimental: Part 1: A reflux and dtir bar wew placed in a 50 mL round-bottomed flask Observation: Part 1: - When Thymine Hydrochloride was added to the flask- white powder. - Water was clear and the mixture was a white and cloudy mixture after ethanol was added - After cooled in ice bath- condensation was present and it looked milky and chunky; white - When precooled Sodium Hydroxide was added it became yellow and changed back to white and cloudy and completely yellow when the remainder was added. - pH was 8 when it was first tested - Final pH was close to 10. - When Benzaldehyde was added slowly the mixture looked like a mixture of water and oil but settle back to liquid. - During heating and reflex: mixture was yellowish with a tint of orange. - After cooled: mixture looked off white, thick and solid/slurry. - Ethanol was added to solid to recrystallize and boiled: liquid was yellowish and a bit clear but turbid. Part 2: - Whilst mixture was being stirred and heated it gradually went from a milky white to a clear green and then to a turbid cloudy green.
Clean Up: Solid organic products go into the solid waste. All filtrates from reactions go into aqueous waste after neutralization. All filtrated from recrystallizations of organic waste. TLC plates go into silica waste. TLC samples dissolved in dichloromethane go into organic halide waste. TLC and melting point capillaries go into glass waste.
- CHEM
- March 27,
- CHEM
- March 27,
- CHEM
- March 27,
Synthesis of Phenytoin
Course: Organic Chemistry II (CHEM 3223)
University: Texas Woman's University
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