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Reverse Vaccinology

PDF ON Reverse Vaccinology
Course

anatomy and bioinformatics (29bif)

7 Documents
Students shared 7 documents in this course
Academic year: 2022/2023
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Mangalore University

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Reverse Vaccinology

The process of finding potential vaccine targets inside the genomes of pathogens is referred to as "reverse vaccinology," and it is one of the more recent developments in the field of vaccine development.

This method has had a profound impact on the development of vaccines, leading to the identification of highly effective preventative measures for a wide variety of infectious diseases.

Principles Governing the Practice of Reverse

Vaccinology

The process involves applying computational approaches to find potential vaccine targets within the genomes of pathogens.

The primary goal of this research is to identify proteins that are present on the surface of the pathogen and are necessary for the pathogen's continued existence or continued virulence.

The ability of vaccines to target specific proteins enables them to stimulate an immune response that guards against disease.

The Origins and Development of Reverse Vaccinology

It was in Asian countries that the first accounts of employing this kind of treatment were found. Lesions of smallpox were utilized as injectable material to defend against infections and dangerous diseases back then.

Then, in the year 1796, Edward Jenner came up with the word "Vaccine" to describe the injectable substance obtained from cows and transmitted to persons who were suffering from smallpox.

The discovery by Louis Pasteur in the 1800s that diseases were caused by microbes laid the groundwork for a rational vaccine production process and established a basic guideline that must be observed while doing vaccinology.

This rule states, 'isolate, inactivate, and inject the microorganism' for the purpose of making a vaccine against the disease caused by the microorganism.

By the time the 20th century came to a close, each and every vaccination had been created by adhering to the Pasteur rule of vaccinology.

However, with the advent of new technologies such as recombinant DNA and the chemical conjugation of proteins to other macromolecules like polysaccharides, progress was made in the field of vaccine production.

And when Craig Venter deduced the 'genome' of the first free-living organism, which completely changed the way vaccines were developed.

The genome of a particular bacterium was analyzed by scientists using computer methods, which allowed them to build vaccines without the requirement for the microorganism to first be grown on culture media in a laboratory.

The bacterial pathogen known as 'Men B' (meningococcus), which is responsible for fifty percent of all cases of meningococcal meningitis in the globe, was the first pathogen that was investigated using the reverse vaccinology method.

Vaccines against Streptococcus bacteria that were developed via the use of reverse vaccinology comprise four proteins that are able

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Reverse Vaccinology

Course: anatomy and bioinformatics (29bif)

7 Documents
Students shared 7 documents in this course

University: Mangalore University

Was this document helpful?
Reverse Vaccinology
The process of finding potential vaccine targets inside the genomes
of pathogens is referred to as "reverse vaccinology," and it is one of
the more recent developments in the field of vaccine development.
This method has had a profound impact on the development of
vaccines, leading to the identification of highly effective
preventative measures for a wide variety of infectious diseases.
Principles Governing the Practice of Reverse
Vaccinology
The process involves applying computational approaches to find
potential vaccine targets within the genomes of pathogens.
The primary goal of this research is to identify proteins that are
present on the surface of the pathogen and are necessary for the
pathogen's continued existence or continued virulence.
The ability of vaccines to target specific proteins enables them to
stimulate an immune response that guards against disease.
The Origins and Development of Reverse Vaccinology
It was in Asian countries that the first accounts of employing this
kind of treatment were found. Lesions of smallpox were utilized as
injectable material to defend against infections and dangerous
diseases back then.

Students also viewed

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