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Drug Study - Olanzapine, Divalproex sodium
Course: Science technology
44 Documents
Students shared 44 documents in this course
University: Southeast Asian College
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Drug
Name
Classification
Mechanism of
Action
Indication
Contraindication
Adverse
Reaction
Nursing Responsibilities
Generic
Name:
Olanzapine
Brand
Name:
Lybalvi,
Olazax,
Symbyax,
Zalasta,
Zypadhera
, Zyprexa
Actual
dosage,
route,
frequency
:
Adult -
1 tab, 10
mg, qhs
PO
Atypical
Antipsychotic
The effect of
olanzapine in
the D2 receptor
is reported to
produce the
positive effects
of this drug
such as a
decrease in
hallucinations,
delusions,
disorganized
speech,
disorganized
thought, and
disorganized
behavior. On
the other hand,
its effect on the
serotonin
5HT2A receptor
prevents the
onset of
anhedonia, flat
affect, alogia,
avolition and
poor attention.
Treatment
of Acute
agitation,
Delirium
Management
of Bipolar 1
disorder,
Schizophrenia
Contraindicated
with allergy to
olanzapine,
myeloproliferativ
e disorders,
severe CNS
depression,
comatose states,
lactation.
Use cautiously in
elderly or
debilitated
patients, or with
CV or
cerebrovascular
disease,
dehydration,
seizure disorders,
Alzheimer's
disease, prostate
enlargement,
narrow-angle
glaucoma,
history of
paralytic ileus or
breast cancer,
pregnancy.
CNS:
Somnolence,
dizziness,
nervousness,
headache,
akathisia,
personality
disorders, tardive
dyskinesia,
neuroleptic
malignant
syndrome
CV: Orthostatic
hypotension,
peripheral edema,
tachycardia
GI: Constipation,
abdominal pain
Respiratory:
Cough,
pharyngitis
Other: Fever,
weight gain, joint
pain, development
of diabetes
mellitus
Before:
Assess for: allergy,
contraindications.
Obtain: baseline VS, weight,
labs, ECG, bowel sounds,
CBC, urinalysis, liver and
renal function tests
During:
Monitor elderly patients for
dehydration and institute
remedial measures promptly;
· Encourage patient to void
before taking the drug
· Monitor for elevations of
temperature and differentiate
between infection and
neuroleptic malignant
syndrome.
· Monitor for orthostatic
hypotension and provide
appropriate safety measures
as needed.
After:
Monitor for signs of adverse
reactions.
Perform health teaching.